COOPERATIVITY BETWEEN PLATELET-ACTIVATING FACTOR AND COLLAGEN IN AGGREGATION OF BOVINE PLATELETS .2.

被引：5

作者：

KOJIMA, S

SEKIYA, F

INADA, Y

TSUKADA, T

SAITO, Y

机构：

[1] TOKYO INST TECHNOL,DEPT BIOL SCI,MEGURO KU,TOKYO 152,JAPAN

[2] TOIN UNIV YOKOHAMA,DEPT MAT SCI & TECHNOL,MIDORI KU,YOKOHAMA,KANAGAWA 227,JAPAN

[3] OKINAKA MEM INST MED RES,MINATO KU,TOKYO 105,JAPAN

[4] TORANOMON GEN HOSP,DIV HEMATOL RES,TOKYO 107,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)91169-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When subthreshold amounts of platelet-activating factor (PAF) and collagen were added simultaneously, strong aggregation of platelets was induced. However, each agonist alone at these concentrations could not induce aggregation at all (S. Kojima etal, (1987) Biochem.Biophys.Res.Commun.145, 915-920). This cooperativity was observed not only in aggregation but also in changes of intracellular Ca2+ concentration, 47 kDa protein phosphorylation, and formation of thromboxane. These findings suggest that various steps of signal transduction pathways are enhanced during their cooperativity. © 1990.

引用

页码：1292 / 1296

页数：5