PROSTAGLANDINS IN THE PATHOGENESIS OF THE GENERALIZED SHWARTZMAN REACTION

被引：8
作者：
LATOUR, JG [1 ]
LEGERGAUTHIER, C [1 ]
机构：
[1] UNIV MONTREAL,FAC MED,DEPT PATHOL,MONTREAL H3C 3J7,QUEBEC,CANADA
来源：
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1979年 / 135卷 / 05期
关键词：
D O I：
10.1016/S0002-9378(16)32979-9
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The GSR induced by a single injection of endotoxin in pregnant rats and cortisone-sensitized rabbits was prevented by bradykinin. The action is mediated by prostaglandins, such as evidenced by: abolition of the effect of bradykinin by aspirin; prevention of the Shwartzman reaction by infusions of PGA2 and PGE1; and sensitization of the normal male rat to the generalized Shwartzman reaction by indomethacin. The mechanism appears to be a neutralization of the essential α-adrenergic component of the generalized Shwartzman reaction.
引用
收藏
页码：577 / 580
页数：4
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