BINDING AND REGULATION OF CELLULAR FUNCTIONS BY MONOCLONAL-ANTIBODIES AGAINST HUMAN TUMOR-NECROSIS-FACTOR RECEPTORS

被引：205

作者：

SHALABY, MR

SUNDAN, A

LOETSCHER, H

BROCKHAUS, M

LESSLAUER, W

ESPEVIK, T

机构：

[1] UNIV TRONDHEIM,INST CANC RES,N-7006 TRONDHEIM,NORWAY

[2] F HOFFMANN LA ROCHE & CO LTD,CENT RES UNIT,CH-4002 BASEL,SWITZERLAND

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 172卷 / 05期

关键词：

D O I：

10.1084/jem.172.5.1517

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study was undertaken to further characterize the interaction ofmonoclonal antibodies (mAbs) against tumor necrosis factor (TNF) receptors with different targets, and to assess their ability to influence TNF effects on U937 and human endothelial cell (HEC) functions. Actions of recombinant TNF-a on U937 and HEC were effectively inhibited by Htr-5 and Utr-1, and to a greater extent by a combination ofboth mAbs. These observations indicate that TNF interaction with antigenically different components of membrane receptors (p55 and p75) represents a crucial step in transduction of signals for TNF toxicity against U937 and TNF activation of HEC functions. © 1990, Rockefeller University Press., All rights reserved.

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页码：1517 / 1520

页数：4

相关论文

共 15 条

[1] IDENTIFICATION OF 2 TYPES OF TUMOR-NECROSIS-FACTOR RECEPTORS ON HUMAN CELL-LINES BY MONOCLONAL-ANTIBODIES [J].

BROCKHAUS, M ;

SCHOENFELD, HJ ;

SCHLAEGER, EJ ;

HUNZIKER, W ;

LESSLAUER, W ;

LOETSCHER, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :3127-3131

[2] THE ROLE OF CACHECTIN/TNF IN ENDOTOXIC-SHOCK AND CACHEXIA [J].

CERAMI, A ;

BEUTLER, B .

IMMUNOLOGY TODAY, 1988, 9 (01) :28-31

[3] CHARACTERIZATION OF BINDING AND BIOLOGICAL EFFECTS OF MONOCLONAL-ANTIBODIES AGAINST A HUMAN TUMOR NECROSIS FACTOR RECEPTOR [J].

ESPEVIK, T ;

BROCKHAUS, M ;

LOETSCHER, H ;

NONSTAD, U ;

SHALABY, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (02) :415-426

[4] STIMULATION OF THE ADHERENCE OF NEUTROPHILS TO UMBILICAL VEIN ENDOTHELIUM BY HUMAN RECOMBINANT TUMOR-NECROSIS-FACTOR [J].

GAMBLE, JR ;

HARLAN, JM ;

KLEBANOFF, SJ ;

VADAS, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8667-8671

[5]

HOHMANN HP, 1989, J BIOL CHEM, V264, P14927

[6]

KRAMER SM, 1986, J IMMUNOL METHODS, V93, P210

[7] MOLECULAR-CLONING AND EXPRESSION OF THE HUMAN 55-KD TUMOR-NECROSIS-FACTOR RECEPTOR [J].

LOETSCHER, H ;

PAN, YCE ;

LAHM, HW ;

GENTZ, R ;

BROCKHAUS, M ;

TABUCHI, H ;

LESSLAUER, W .

CELL, 1990, 61 (02) :351-359

[8] HUMAN-TUMOR NECROSIS FACTOR - PRECURSOR STRUCTURE, EXPRESSION AND HOMOLOGY TO LYMPHOTOXIN [J].

PENNICA, D ;

NEDWIN, GE ;

HAYFLICK, JS ;

SEEBURG, PH ;

DERYNCK, R ;

PALLADINO, MA ;

KOHR, WJ ;

AGGARWAL, BB ;

GOEDDEL, DV .

NATURE, 1984, 312 (5996) :724-729

[9] MOLECULAR-CLONING AND EXPRESSION OF A RECEPTOR FOR HUMAN TUMOR-NECROSIS-FACTOR [J].

SCHALL, TJ ;

LEWIS, M ;

KOLLER, KJ ;

LEE, A ;

RICE, GC ;

WONG, GHW ;

GATANAGA, T ;

GRANGER, GA ;

LENTZ, R ;

RAAB, H ;

KOHR, WJ ;

GOEDDEL, DV .

CELL, 1990, 61 (02) :361-370

[10] RECEPTOR-BINDING AND ACTIVATION OF POLYMORPHONUCLEAR NEUTROPHILS BY TUMOR-NECROSIS-FACTOR-ALPHA [J].

SHALABY, MR ;

PALLADINO, MA ;

HIRABAYASHI, SE ;

EESSALU, TE ;

LEWIS, GD ;

SHEPARD, HM ;

AGGARWAL, BB .

JOURNAL OF LEUKOCYTE BIOLOGY, 1987, 41 (03) :196-204