BRADYKININ RECEPTORS IN ISOLATED RAT DUODENUM

被引：13
|
作者：
ALTINKURT, O
OZTURK, Y
机构：
[1] UNIV ANKARA,FAC PHARM,DEPT PHARMACOL,ANKARA 06100,TURKEY
[2] UNIV ANATOLIA,ESKISEHIR 26470,TURKEY
来源：
PEPTIDES | 1990年 / 11卷 / 01期
关键词：
B[!sub]1[!/sub] and B[!sub]2[!/sub] receptors; Bradykinin; des-Arg[!sup]9[!/sup]]-Bradykinin;
D O I：
10.1016/0196-9781(90)90107-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pharmacological properties of the bradykinin receptors in the isolated rat duodenum were investigated by examining the relaxant and contractile responses to bradykinin and [des-Arg9]-bradykinin, an agonist of B1 receptors. A specific desensitization and de novo formation for B1 receptors were observed. Changes in medium pH caused a decrease in the responses to bradykinin and [des-Arg9]-bradykinin of rat duodenum. Urea incubation in test tube inhibited the responses to bradykinin and [des-Arg9]-bradykinin of rat duodenum, while urea in bathing medium was ineffective. These findings strongly suggested that (a) ionic bonds are important in the interaction between bradykinin and its receptors, and (b) B2 receptors in rat duodenum are different from those in guinea pig ileum. © 1990.
引用
收藏
页码：39 / 44
页数：6
相关论文
共 50 条
12345