BIOLOGICAL PROPERTIES OF A CD4 IMMUNOADHESIN

被引：157

作者：

BYRN, RA ^{[1
]}

MORDENTI, J ^{[1
]}

LUCAS, C ^{[1
]}

SMITH, D ^{[1
]}

MARSTERS, SA ^{[1
]}

JOHNSON, JS ^{[1
]}

COSSUM, P ^{[1
]}

CHAMOW, SM ^{[1
]}

WURM, FM ^{[1
]}

GREGORY, T ^{[1
]}

GROOPMAN, JE ^{[1
]}

CAPON, DJ ^{[1
]}

机构：

[1] HARVARD UNIV,NEW ENGLAND DEACONESS HOSP,SCH MED,DIV HEMATOL ONCOL,BOSTON,MA 02215

来源：

NATURE | 1990年 / 344卷 / 6267期

关键词：

D O I：

10.1038/344667a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MOLECULAR fusions of CD4, the receptor for human immunodeficiency virus (HIV; refs 1-4), with immunoglobulin (termed CD4 immunoadhesins) possess both the gpl20-binding and HIV-blocking properties of recombinant soluble CD4, and certain properties of IgG, notably long plasma half-life and Fc receptor binding5,6. Here we show that a CD4 immunoadhesin can mediate antibody-dependent cell-mediated cytotoxicity (ADCC) towards HIV-infected cells, although, unlike natural anti-gpl20 antibodies, it does not allow ADCC towards uninfected CD4-expressing cells that have bound soluble gpl20 to the CD4 on their surface. In addition, CD4 immunoadhesin, like natural IgG molecules, is efficiently transferred across the placenta of a primate. These observations have implications for the therapeutic application of CD4 immunoadhesins, particularly in the area of perinatal transmission of HIV infection. © 1990 Nature Publishing Group.

引用

页码：667 / 670

页数：4

共 20 条

[1] DESIGNING CD4 IMMUNOADHESINS FOR AIDS THERAPY [J].

CAPON, DJ ;

CHAMOW, SM ;

MORDENTI, J ;

MARSTERS, SA ;

GREGORY, T ;

MITSUYA, H ;

BYRN, RA ;

LUCAS, C ;

WURM, FM ;

GROOPMAN, JE ;

BRODER, S ;

SMITH, DH .

NATURE, 1989, 337 (6207) :525-531

[2] SELECTIVE KILLING OF HIV-INFECTED CELLS BY RECOMBINANT HUMAN CD4-PSEUDOMONAS EXOTOXIN HYBRID PROTEIN [J].

CHAUDHARY, VK ;

MIZUKAMI, T ;

FUERST, TR ;

FITZGERALD, DJ ;

MOSS, B ;

PASTAN, I ;

BERGER, EA .

NATURE, 1988, 335 (6188) :369-372

[3] THE CD4 (T4) ANTIGEN IS AN ESSENTIAL COMPONENT OF THE RECEPTOR FOR THE AIDS RETROVIRUS [J].

DALGLEISH, AG ;

BEVERLEY, PCL ;

CLAPHAM, PR ;

CRAWFORD, DH ;

GREAVES, MF ;

WEISS, RA .

NATURE, 1984, 312 (5996) :763-767

[4] PLACENTAL TRANSFER OF PROTEINS IN HUMAN GESTATION [J].

DANCIS, J ;

ORATZ, M ;

LIND, J ;

VARA, P ;

SMOLENS, J .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1961, 82 (01) :167-&

[5] SELECTIVITY OF HUMAN PLACENTA IN TRANSFER OF PLASMA PROTENS FROM MOTHER TO FETUS [J].

GITLIN, D ;

URRUSTI, J ;

MORALES, C ;

KUMATE, J .

JOURNAL OF CLINICAL INVESTIGATION, 1964, 43 (10) :1938-&

[6]

HOWELL DN, 1985, J IMMUNOL, V134, P971

[7] REVIEW ARTICLE - FC-GAMMA-RECEPTORS IN THE HUMAN-PLACENTA [J].

JOHNSON, PM ;

BROWN, PJ .

PLACENTA, 1981, 2 (04) :355-369

[8]

Kabat E. A., 1987, SEQUENCES PROTEINS I, DOI 10.1016/0003-2697(84)90805-4

[9] HUMAN IMMUNODEFICIENCY VIRUS-INFECTION OF NEWBORNS [J].

KATZ, SL ;

WILFERT, CM .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (25) :1687-1689

[10] LYMPHOCYTE-T T4 MOLECULE BEHAVES AS THE RECEPTOR FOR HUMAN RETROVIRUS LAV [J].

KLATZMANN, D ;

CHAMPAGNE, E ;

CHAMARET, S ;

GRUEST, J ;

GUETARD, D ;

HERCEND, T ;

GLUCKMAN, JC ;

MONTAGNIER, L .

NATURE, 1984, 312 (5996) :767-768

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