EFFECT OF CO-TRIMOXAZOLE ON RENAL CREATININE EXCRETION IN MAN

Clinical observations have shown, that administration of Co-trimoxazole (Trimethoprim-Sulfamethoxazole) may result in an elevation of the serum-creatinine level. In 27 subjects the endogenous creatinine- and inulinclearance were measured before and during oral or parenteral application of Co-trimoxazole. The inulinclearance showed no significant differences (p>0,05). But the endogenous creatinine clearance showed a reduction of 18% during the oral and of 13% during the parenteral treatment (p≦0,05) These observations indicate a functional inhibition of the tubular creatinine secretion by Co-trimoxazole. © 1979 Springer-Verlag.