Radiobiological comparison of two radiotherapy treatment techniques for high-risk prostate cancer

Background: To make a radiobiological comparison, for high risk prostate cancer (T3a, PSA> 20 ng/ml or Gleason> 7) of two radiotherapy treatment techniques. One technique consists of a treatment in three phases of the pelvic nodes, vesicles and prostate using a conventional fractionation scheme of 2 Gy/fraction (SIMRT). The other technique consists of a treatment in two phases that gives simultaneously different dose levels in each phase, 2 Gy/fraction, 2.25 Gy/fraction and 2.5 Gy/fraction to the pelvic nodes, vesicles and prostate, respectively (SIBIMRT). Materials and methods: The equivalent dose at fractionation of 2 Gy (EQD(2)), calculated using the linear quadratic model with alpha/beta(prostate) = 1.5 Gy, was the same for both treatment strategies. For comparison the parameters employed were D95, mean dose and Tumour Control Probabilities for prostate PTV and D15, D25, D35, D50, mean dose and Normal Tissue Complication Probabilities for the rectum and bladder, with physical doses converted to EQD(2). Parameters were obtained for alpha/beta(prostate) = 1.5, 3 and 10 Gy and for alpha/beta(oar) 1, 2, 3, 4, 6 and 8. Results: For prostate PTV, both treatment strategies are equivalent for alpha/beta(prostate) = 1.5 Gy but for higher alpha/beta(prostate), EQD(2) and TCP, decrease for the SIBIMRT technique. For the rectum and bladder when alpha/beta(oar) <= 2 Gy, EQD(2) and NTCP are lower for the SIMRT technique or equal in both techniques. For alpha/beta(oar) >= 2-3 Gy, EQD(2) and NTCP increase for the SIMRT treatment. Conclusions: A comparison between two radiotherapy techniques is presented. The SIBIMRT technique reduces EQD(2) and NTCP for alpha/beta(oar) from 2 to 8 Gy. (C) 2013 Greater Poland Cancer Centre. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.