LOCALIZATION OF APOPTOSIS (PROGRAMMED CELL-DEATH) IN MICE BY ADMINISTRATION OF LIPOPOLYSACCHARIDE

被引：42
|
作者：
ZHANG, XM [1 ]
MORIKAWA, A [1 ]
TAKAHASHI, K [1 ]
JIANG, GZ [1 ]
KATO, Y [1 ]
SUGIYAMA, T [1 ]
KAWAI, M [1 ]
FUKADA, M [1 ]
YOKOCHI, T [1 ]
机构：
[1] AICHI MED UNIV, DEPT MICROBIOL, AICHI 48011, JAPAN
来源：
MICROBIOLOGY AND IMMUNOLOGY | 1994年 / 38卷 / 08期
关键词：
LPS; APOPTOSIS; THYMUS; DNA FRAGMENTATION;
D O I：
10.1111/j.1348-0421.1994.tb01838.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Localization of apoptotic cells by administration of lipopolysaccharide into mice was studied by using the in situ specific labeling of fragmented DNA. This method clearly stained the nuclei of thymocytes at the cortex of the thymus. The nuclei of cells in the bone marrow and in the spleen were also positively stained. It was suggested that the cortex in the thymus is where the LPS-induced programmed cell death occurs.
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页码：669 / 671
页数：3
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