A COMPARATIVE STUDY BETWEEN I.V 50% MAGNESIUM SULPHATE AND DEXMEDETOMIDINE FOR ATTENUATION OF CARDIOVASCULAR STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

BACKGROUND: Direct laryngoscopy and endotracheal intubation frequently induces a cardiovascular stress response due to reflex sympathetic stimulation. This response may be hazardous in patients with hypertension, coronary artery disease, myocardial disease, cerebrovascular disease. Numerous agents have therefore been utilized to blunt this response. OBJECTIVES: The present study was undertaken in view of above mentioned facts, to compare effectiveness of intravenous Magnesium sulphate and Dexmedetomidine in suppressing the cardiovascular stress response. METHODS: 60 Patients were divided in to two groups of 30 patients each. Group-M received 30mg/kg of Magnesium sulphate and Group-D received 1 mic/kg Dexmedetomidine ten minutes before intubation. Both the groups were observed for changes in hemodynamic parameters i. e. heart rate (HR) systolic and diastolic blood pressure at 0, 1, 3, 5, 10 minutes post intubation. RESULTS: Statistical analysis was performed using SPSS version 20 (USA). It was observed that both magnesium sulphate and dexmedetomidine attenuated the rise in systolic and diastolic blood pressure, but magnesium failed to attenuate increase in the heart rate which is less than 10 beats/min. compared to dexmedetomidine which effectively controlled the rise heart rate following intubation. CONCLUSION: Our study proves that magnesium sulphate is as effective as dexmedetomidine in attenuating the cardiovascular stress response to laryngoscopy and endotracheal intubation.