EXPRESSION OF INTERLEUKIN-1-ALPHA AND INTERLEUKIN-1 RECEPTOR TYPE-I GENES IN MURINE BROWN ADIPOSE-TISSUE

被引：13

作者：

BURYSEK, L

TVRDIK, P

HOUSTEK, J

机构：

[1] Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague

来源：

FEBS LETTERS | 1993年 / 334卷 / 02期

关键词：

GENE EXPRESSION; IL-1-ALPHA; IL-1RTI; BROWN ADIPOSE TISSUE; COLD THERMOGENESIS; LIPOPOLYSACCHARIDE;

D O I：

10.1016/0014-5793(93)81717-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

At thermoneutral conditions, high steady-state levels of transcripts for both IL-1alpha and its receptor IL-1RtI were found in specialized thermogenic organ, brown adipose tissue (BAT) of adult mice, as compared with the levels in lymph nodes, brain and spleen. A pronounced decrease of IL-1alpha mRNA level in BAT was observed after lipopolysaccharide (LPS) administration and after exposure to cold. Likewise, LPS decreased the IL-1RtI mRNA level and depressed also the expression of cold-inducible genes for the BAT-specific heat-producing uncoupling protein and for lipoprotein lipase. It is concluded that, besides the centrally-mediated effects, there exists a direct peripheral interaction of IL-1 cytokines with BAT cells.

引用

页码：229 / 232

页数：4

共 38 条

[1]

ARNOLD J, 1990, CIRC SHOCK, V31, P387

[2]

BIRD TA, 1989, J IMMUNOL, V142, P126

[3] EFFECT OF PROPRANOLOL ON ENDOTOXIN-INDUCED PYROGENESIS IN NEWBORN AND ADULT GUINEA-PIGS [J].