UP-REGULATION OF FOREBRAIN PROENKEPHALIN MESSENGER-RNA SUBSEQUENT TO NMDA RECEPTOR BLOCKADE

被引：19

作者：

ANGULO, JA ^{[1
]}

WATANABE, Y ^{[1
]}

CADET, J ^{[1
]}

LEDOUX, M ^{[1
]}

MCEWEN, BS ^{[1
]}

机构：

[1] NIDA,BETHESDA,MD

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1993年 / 244卷 / 03期

关键词：

NMDA RECEPTORS; GLUTAMATE; PROENKEPHALIN MESSENGER RNA; STRIATUM; ACCUMBENS; MK; 801;

D O I：

10.1016/0922-4106(93)90158-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Blockade of NMDA (N-methyl-D-aspartate) receptors for 5 h with MK 801 resulted in elevated levels of proenkephalin mRNA (up to 40% above vehicle-injected controls) in medial and anterior aspects of the caudate-putamen (mCPU and aCPU) and the nucleus accumbens (NAc). Increases were dose-dependent, with maximal effect at 0.1 mg/kg (body weight). These results suggest that NMDA receptor activity exerts tonic inhibition on proenkephalin mRNA expression in the striatum and accumbens of the rat brain.

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收藏

页码：317 / 318

页数：2

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