UP-REGULATION OF FOREBRAIN PROENKEPHALIN MESSENGER-RNA SUBSEQUENT TO NMDA RECEPTOR BLOCKADE

被引：19
|
作者：
ANGULO, JA [1 ]
WATANABE, Y [1 ]
CADET, J [1 ]
LEDOUX, M [1 ]
MCEWEN, BS [1 ]
机构：
[1] NIDA,BETHESDA,MD
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1993年 / 244卷 / 03期
关键词：
NMDA RECEPTORS; GLUTAMATE; PROENKEPHALIN MESSENGER RNA; STRIATUM; ACCUMBENS; MK; 801;
D O I：
10.1016/0922-4106(93)90158-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Blockade of NMDA (N-methyl-D-aspartate) receptors for 5 h with MK 801 resulted in elevated levels of proenkephalin mRNA (up to 40% above vehicle-injected controls) in medial and anterior aspects of the caudate-putamen (mCPU and aCPU) and the nucleus accumbens (NAc). Increases were dose-dependent, with maximal effect at 0.1 mg/kg (body weight). These results suggest that NMDA receptor activity exerts tonic inhibition on proenkephalin mRNA expression in the striatum and accumbens of the rat brain.
引用
收藏
页码：317 / 318
页数：2
相关论文
共 50 条
12345