3-PHENYL-4-HYDROXYQUINOLIN-2(1H)-ONES - POTENT AND SELECTIVE ANTAGONISTS AT THE STRYCHNINE-INSENSITIVE GLYCINE SITE ON THE N-METHYL-D-ASPARTATE RECEPTOR COMPLEX

被引：83

作者：

MCQUAID, LA ^{[1
]}

SMITH, ECR ^{[1
]}

LODGE, D ^{[1
]}

PRALONG, E ^{[1
]}

WIKEL, JH ^{[1
]}

CALLIGARO, DO ^{[1
]}

OMALLEY, PJ ^{[1
]}

机构：

[1] UNIV LONDON ROYAL VET COLL,LONDON NW1 0TU,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 18期

关键词：

D O I：

10.1021/jm00096a019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3423 / 3425

页数：3

共 25 条

[1]

BARON BM, 1990, MOL PHARMACOL, V38, P554

[2] 6,7-DINITRO-QUINOXALINE-2,3-DION AND 6-NITRO,7-CYANO-QUINOXALINE-2,3-DION ANTAGONIZE RESPONSES TO NMDA IN THE RAT SPINAL-CORD VIA AN ACTION AT THE STRYCHNINE-INSENSITIVE GLYCINE RECEPTOR [J].

BIRCH, PJ ;

GROSSMAN, CJ ;

HAYES, AG .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 156 (01) :177-180

[3] 2-CARBOXYTETRAHYDROQUINOLINES - CONFORMATIONAL AND STEREOCHEMICAL REQUIREMENTS FOR ANTAGONISM OF THE GLYCINE SITE ON THE NMDA RECEPTOR [J].

CARLING, RW ;

LEESON, PD ;

MOSELEY, AM ;

BAKER, R ;

FOSTER, AC ;

GRIMWOOD, S ;

KEMP, JA ;

MARSHALL, GR .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (11) :1942-1953

[4] GLYCINE REVERSES ANTAGONISM OF N-METHYL-D-ASPARTATE (NMDA) BY 1-HYDROXY-3-AMINOPYRROLIDONE-2 (HA-966) BUT NOT BY D-2-AMINO-5-PHOPHONOVALERATE (D-AP5) ON RAT CORTICAL SLICES [J].

FLETCHER, EJ ;

LODGE, D .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 151 (01) :161-162

[5]

FOSTER AC, 1989, J NEUROSCI, V9, P2191

[6] NOVEL INDOLE-2-CARBOXYLATES AS LIGANDS FOR THE STRYCHNINE-INSENSITIVE N-METHYL-D-ASPARTATE-LINKED GLYCINE RECEPTOR [J].

GRAY, NM ;

DAPPEN, MS ;

CHENG, BK ;

CORDI, AA ;

BIESTERFELDT, JP ;

HOOD, WF ;

MONAHAN, JB .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (04) :1283-1292

[7]

Hansch C, 1979, SUBSTITUENT CONSTANT

[8] 4-[(CARBOXYMETHYL)OXY]-5,7-DICHLOROQUINOLINE-2-CARBOXYLIC AND 4-[(CARBOXYMETHYL)AMINO]-5,7-DICHLOROQUINOLINE-2-CARBOXYLIC ACID - NEW ANTAGONISTS OF THE STRYCHNINE-INSENSITIVE GLYCINE BINDING-SITE ON THE N-METHYL-D-ASPARTATE RECEPTOR COMPLEX [J].

HARRISON, BL ;

BARON, BM ;

COUSINO, DM ;

MCDONALD, IA .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (12) :3130-3132

[9] H-1, F-19 AND C-13 NMR ASSIGNMENTS OF 5,7-DIHALOGENATED KYNURENIC ACID-DERIVATIVES [J].

HUBER, EW ;

STEMERICK, DM ;

COUSINO, DM ;

HARRISON, BL .

MAGNETIC RESONANCE IN CHEMISTRY, 1991, 29 (08) :859-860

[10] GLYCINE POTENTIATES THE NMDA RESPONSE IN CULTURED MOUSE-BRAIN NEURONS [J].

JOHNSON, JW ;

ASCHER, P .

NATURE, 1987, 325 (6104) :529-531

← 1 2 3 →