A CHORIONIC GONADOTROPIN-SECRETING HUMAN PITUITARY CELL

被引：28
作者：
HAMMOND, E
GRIFFIN, J
ODELL, WD
机构：
[1] UNIV UTAH, SCH MED, DEPT MED, 50 N MED DR, SALT LAKE CITY, UT 84132 USA
[2] UNIV UTAH, SCH MED, DEPT PATHOL, SALT LAKE CITY, UT 84132 USA
来源：
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1991年 / 72卷 / 04期
关键词：
D O I：
10.1210/jcem-72-4-747
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent data from our laboratory show that hCG is secreted in a pulsatile manner in parallel with human LH (hLH) in nonpregnant normal humans. Furthermore, GnRH stimulates hCG and hLH release. Using a monoclonal antibody specific for the beta-chain of hCG and not reacting with hLH, we have identified a heretofore unknown cell type in human pituitaries which stains only for hCG. The light microscopic, immunocytochemical, and ultrastructural features are described. These data coupled to those from multiple earlier studies indicate that hCG is secreted by these cells in normal nonpregnant humans.
引用
收藏
页码：747 / 754
页数：8
相关论文
共 20 条
  • [1] HUMAN CHORIONIC-GONADOTROPIN IN THE PLASMA OF NORMAL, NON-PREGNANT SUBJECTS
    BORKOWSKI, A
    MUQUARDT, C
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1979, 301 (06) : 298 - 302
  • [2] HUMAN CHORIONIC GONADOTROPIN-LIKE SUBSTANCE IN PLASMA OF NORMAL NONPREGNANT SUBJECTS AND WOMEN WITH BREAST-CANCER
    BORKOWSKI, A
    PUTTAERT, V
    GYLING, M
    MUQUARDT, C
    BODY, JJ
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1984, 58 (06) : 1171 - 1178
  • [3] BRANDTZAEG P, 1982, IMMUNOFLUORESCENCE T, P167
  • [4] BRAUNSTEIN GD, 1979, J CLIN ENDOCR METAB, V49, P917
  • [5] PRESENCE IN NORMAL HUMAN TESTES OF A CHORIONIC-GONADOTROPIN-LIKE SUBSTANCE DISTINCT FROM HUMAN LUTEINIZING-HORMONE
    BRAUNSTEIN, GD
    RASOR, J
    WADE, ME
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1975, 293 (26) : 1339 - 1343
  • [6] EVIDENCE FOR A GONADOTROPIN FROM NONPREGNANT SUBJECTS THAT HAS PHYSICAL, IMMUNOLOGICAL, AND BIOLOGICAL SIMILARITIES TO HUMAN CHORIONIC-GONADOTROPIN
    CHEN, H
    HODGEN, GD
    MATSUURA, S
    LIN, LJ
    GROSS, E
    REICHERT, LE
    BIRKEN, S
    CANFIELD, RE
    ROSS, GT
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (08) : 2885 - 2889
  • [7] DVORAK AM, 1972, LAB INVEST, V27, P561
  • [8] ULTRASENSITIVE IMMUNORADIOMETRIC ASSAY FOR CHORIONIC-GONADOTROPIN WHICH DOES NOT CROSS-REACT WITH LUTEINIZING-HORMONE NOR FREE BETA-CHAIN OF HCG AND WHICH DETECTS HCG IN BLOOD OF NONPREGNANT HUMANS
    GRIFFIN, J
    ODELL, WD
    [J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1987, 103 (02) : 275 - 283
  • [9] STUDIES OF THE HUMAN CHORIONIC GONADOTROPIN-LIKE SUBSTANCE OF HUMAN PITUITARY-GLANDS AND ITS SIGNIFICANCE
    HARTREE, AS
    SHOWNKEEN, RC
    STEVENS, VC
    MATSUURA, S
    OHASHI, M
    CHEN, HC
    [J]. JOURNAL OF ENDOCRINOLOGY, 1983, 96 (01) : 115 - 126
  • [10] KYLE CV, 1988, CLIN RES, V36, pA181
12