CIS DIFUNCTIONALIZATION OF CYCLIC OLEFINS WITH USE OF ORGANOZIRCONIUM INTERMEDIATES

被引：25

作者：

CUNY, GD ^{[1
]}

GUTIERREZ, A ^{[1
]}

BUCHWALD, SL ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

ORGANOMETALLICS | 1991年 / 10卷 / 03期

关键词：

D O I：

10.1021/om00049a006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The utilization of in situ generated zirconocene-benzyne complexes as a means to effect cis carbofunctionalizations of cyclic olefins in a one-pot procedure is described. The stereospecific insertion of cyclic olefins provides the cis-zirconaindane metallacycles exclusively. The intermediate metallacycles were treated with a variety of electrophiles to provide diasteroeselective syntheses of arylcyanoalkanes, tricyclic ketones, and 2,3-dihydrobenzo[b]thiophenes in moderate overall yields.

引用

页码：537 / 539

页数：3

共 27 条

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Sharpless K. B., 1979, ALDRICHIM ACTA, V12, P63

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