STIMULATION OF BLOOD-PLATELETS BY EXTRACTS OF SUBCUTANEOUS TISSUE

被引：12

作者：

BENDER, N ^{[1
]}

KIRCHMAIER, C ^{[1
]}

BARTSCH, B ^{[1
]}

LINDENBORN, D ^{[1
]}

BREDDIN, K ^{[1
]}

机构：

[1] UNIV FRANKFURT, DEPT INTERNAL MED, D-6000 FRANKFURT 70, FED REP GER

来源：

THROMBOSIS RESEARCH | 1979年 / 14卷 / 2-3期

关键词：

D O I：

10.1016/0049-3848(79)90243-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

If [human] blood was fixed at blood sampling by feeding it directly into glutaraldehyde, 15-25% of the platelets showed pseudopods and were spherical, while the majority retained their disc-like shape. When the canula was accidentally inserted into the perivascular tissue and then withdrawn to collect venous blood almost all platelets were spherical and showed pseudopods. Similar morphologic changes could be induced with regularity within 1-2 s by admixing s.c. tissue extracts to freshly drawn blood before fixation. The activity which caused these rapid morphologic changes seemed to be independent of ADP or collagen and more active. It did not induce aggregation but may be important for the initiation of primary hemostasis. Similar effects were obtained with lysolecithin and monophosphoinositit/phosphatidylcholine.

引用

页码：341 / 351

页数：11

共 13 条

[1]

BAMBERG E, BLUT

[2]

Baumgartner HR., 1972, THROMB DIATH HAEMORR, V51, P161

[3]

BORN GVR, 1962, J PHYSIOL-LONDON, V162, pP67

[4]

GAARDER A., 1961, NATURE, V192, P531, DOI 10.1038/192531a0

[5] THROMBOXANES - NEW GROUP OF BIOLOGICALLY-ACTIVE COMPOUNDS DERIVED FROM PROSTAGLANDIN ENDOPEROXIDES [J].

HAMBERG, M ;

SVENSSON, J ;

SAMUELSSON, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) :2994-2998

[6] ROLE OF ADENOSINE DIPHOSPHATE IN AGGREGATION OF HUMAN BLOOD-PLATELETS BY THROMBIN + BY FATTY ACIDS [J].

HASLAM, RJ .

NATURE, 1964, 202 (493) :765-+

[7]

HUGUES J, 1964, THROMB DIATH HAEMOST, V11, P327

[8]

KINLOUGHRATHBONE RL, 1977, J LAB CLIN MED, V90, P707

[9]

LUSCHER EF, 1976, B SCHWEIZ AKAD MED, V32, P161

[10] INITIAL CHANGES IN PLATELET MORPHOLOGY FOLLOWING ADDITION OF ADENOSINE DIPHOSPHATE [J].

MACMILLA.DC ;

OLIVER, MF .

JOURNAL OF ATHEROSCLEROSIS RESEARCH, 1965, 5 (04) :440-&

← 1 2 →