SUPPRESSION OF EXPERIMENTAL ANTIGEN-INDUCED ARTHRITIS IN TRANSGENIC MICE PRODUCING HUMAN ALPHA-FETOPROTEIN

被引：21

作者：

OGATA, A

YAMASHITA, T

KOYAMA, Y

SAKAI, M

NISHI, S

机构：

[1] HOKKAIDO UNIV, SCH MED, DEPT BIOCHEM, KITA KU, SAPPORO, HOKKAIDO 060, JAPAN

[2] HOKKAIDO UNIV, GRAD SCH VET MED, EXPTL ANIM SCI LAB, SAPPORO, HOKKAIDO 060, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 213卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.2138

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Experimental arthritis was induced in the knee joint of transgenic mice expressing human alpha-fetoprotein by immunization with methylated bovine serum albumin in Freund's complete adjuvant. In the control experiment with normal C57BL/6 mice, definite arthritis was observed in 55.6% (5/9) of the mice, but in only 21.1% (4/19) of the transgenic mice. This result suggested that human alpha-fetoprotein functioned as an immunosuppressant to ameliorate the development of the immune disease. (C) 1995 Academic Press, Inc.

引用

页码：362 / 366

页数：5

共 12 条

[1] ANTIGEN-INDUCED ARTHRITIS IN MICE .1. INDUCTION OF ARTHRITIS IN VARIOUS STRAINS OF MICE [J].