A FAMILIAL ALZHEIMERS-DISEASE LOCUS ON CHROMOSOME-1

被引：631
作者：
LEVYLAHAD, E
WIJSMAN, EM
NEMENS, E
ANDERSON, L
GODDARD, KAB
WEBER, JL
BIRD, TD
SCHELLENBERG, GD
机构：
[1] VET ADM MED CTR, CTR GERIATR RES EDUC & CLIN, SEATTLE, WA 98108 USA
[2] UNIV WASHINGTON, DEPT MED, DIV MED GENET, SEATTLE, WA 98195 USA
[3] UNIV WASHINGTON, DEPT BIOSTAT, SEATTLE, WA 98195 USA
[4] MARSHFIELD MED RES FDN, MARSHFIELD, WI 54449 USA
[5] VET AFFAIRS MED CTR, DIV NEUROL, SEATTLE, WA 98108 USA
来源：
SCIENCE | 1995年 / 269卷 / 5226期
关键词：
D O I：
10.1126/science.7638621
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Volga German kindreds are a group of seven related families with autosomal dominant early-onset Alzheimer's disease (AD). Linkage to known AD-related loci on chromosomes 21 and 14 has been excluded. Significant evidence for linkage to AD in these families was obtained with D1S479 and there was also positive evidence for linkage with other markers in the region. A 112-base pair allele of D1S479 co-segregated with the disease in five of seven families, which is consistent with a common genetic founder. This study demonstrates the presence of an AD locus on chromosome 1q31-42.
引用
收藏
页码：970 / 973
页数：4
相关论文
共 49 条
[1]  
BENJAMIN R, 1994, LANCET, V344, P473, DOI 10.1016/S0140-6736(94)91804-X
[2]   PHENOTYPIC HETEROGENEITY IN FAMILIAL ALZHEIMERS-DISEASE - A STUDY OF 24 KINDREDS [J].
BIRD, TD ;
SUMI, SM ;
NEMENS, EJ ;
NOCHLIN, D ;
SCHELLENBERG, G ;
LAMPE, TH ;
SADOVNICK, A ;
CHUI, H ;
MINER, GW ;
TINKLENBERG, J .
ANNALS OF NEUROLOGY, 1989, 25 (01) :12-25
[3]   FAMILIAL ALZHEIMERS-DISEASE IN AMERICAN DESCENDANTS OF THE VOLGA GERMANS - PROBABLE GENETIC FOUNDER EFFECT [J].
BIRD, TD ;
LAMPE, TH ;
NEMENS, EJ ;
MINER, GW ;
SUMI, SM ;
SCHELLENBERG, GD .
ANNALS OF NEUROLOGY, 1988, 23 (01) :25-31
[4]  
BIRD TD, 1992, RES PER ALZ, P118
[5]  
BIRD TD, 1991, AM HIST SOC GERM RUS, V49
[6]  
BOTSTEIN D, 1980, AM J HUM GENET, V32, P314
[7]  
BROUSSEAU T, 1994, NEUROLOGY, V342
[8]   RELEASE OF EXCESS AMYLOID BETA-PROTEIN FROM A MUTANT AMYLOID BETA-PROTEIN PRECURSOR [J].
CAI, XD ;
GOLDE, TE ;
YOUNKIN, SG .
SCIENCE, 1993, 259 (5094) :514-516
[9]  
CAVALLISFORZA LL, 1986, AM J HUM GENET, V38, P599
[10]   EXCESSIVE PRODUCTION OF AMYLOID BETA-PROTEIN BY PERIPHERAL CELLS OF SYMPTOMATIC AND PRESYMPTOMATIC PATIENTS CARRYING THE SWEDISH FAMILIAL ALZHEIMER-DISEASE MUTATION [J].
CITRON, M ;
VIGOPELFREY, C ;
TEPLOW, DB ;
MILLER, C ;
SCHENK, D ;
JOHNSTON, J ;
WINBLAD, B ;
VENIZELOS, N ;
LANNFELT, L ;
SELKOE, DJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (25) :11993-11997
12345