CENTRAL ACTION OF BICUCULLINE

被引：22

作者：

CURTIS, DR ^{[1
]}

JOHNSTON, GA ^{[1
]}

GAME, CJA ^{[1
]}

MCCULLOCH, RM ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV, DEPT PHARMACOL, CANBERRA 260, ACT, AUSTRALIA

来源：

JOURNAL OF NEUROCHEMISTRY | 1974年 / 23卷 / 03期

关键词：

D O I：

10.1111/j.1471-4159.1974.tb06066.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lack of association in vivo between AChE (acetyl cholinesterase) inhibition and antagonism by bicuculline methochloride of the effects on a cholinoceptive neuron of GABA was demonstrated. Renshaw cell (cat) firing, maintained with electrophoretic DL-homocysteic acid (DLH) was readily inhibited by glycine and GABA, and the effect of GABA was reversibly blocked by bicuculline methochloride. Physostigmine salicylate i.v. produced marked enhancement of the excitatory action of ACh, and prolongation of the synaptic response of the cell by a ventral root volley.

引用

页码：605 / 606

页数：2

共 12 条

[1]

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[3]

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[4]

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[5]

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[7] BICUCULLINE, AN ANTAGONIST OF GABA AND SYNAPTIC INHIBITION IN SPINAL CORD OF CAT [J].

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BRAIN RESEARCH, 1971, 32 (01) :69-&

[8] CHOLINERGIC AND INHIBITORY SYNAPSES IN A PATHWAY FROM MOTOR-AXON COLLATERALS TO MOTONEURONES [J].

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[9] BICUCULLINE METHOCHLORIDE AS A GABA ANTAGONIST [J].

JOHNSTON, GA ;

BEART, PM ;

MCCULLOCH, RM ;

MACLACHLAN, RM ;

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CURTIS, DR .

NATURE-NEW BIOLOGY, 1972, 240 (102) :219-+

[10] GAMMA-AMINOBUTYRIC ACID, BICUCULLINE, AND POST-SYNAPTIC BINDING-SITES [J].

PECK, EJ ;

SCHAEFFER, JM ;

CLARK, JH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1973, 52 (02) :394-400

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