PRURIGO NODULARIS - REAPPRAISAL OF THE CLINICAL AND HISTOLOGIC FEATURES

被引：47

作者：

DOYLE, JA

CONNOLLY, SM

HUNZIKER, N

WINKELMANN, RK

机构：

[1] Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 1979年 / 6卷 / 05期

关键词：

D O I：

10.1111/j.1600-0560.1979.tb01161.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Study of 14 patients with prurigo nodularis revealed that clinically the lesions were multiple, verrucous, and discrete and were set in normal‐appearing skin. Microscopically, the lesions showed a vascular acanthomatous mass. The dermal nerves showed a tendency toward hyperplasia in parallel with the epidermal and vascular changes, but no evidence of neuroma formation was seen. Electron microscopic examination showed disorganization of the normal pattern of the myelin sheaths and axons of the dermal papillary nerves. The presence of epidermal mast cells was noted in the biopsy specimens of prurigo nodules from eight of the 14 patients. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：392 / 403

页数：12

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