SUBSTANTIA-NIGRA LESION PROTECTS AGAINST ISCHEMIC DAMAGE IN THE STRIATUM

被引:259
作者
GLOBUS, MYT
GINSBERG, MD
DIETRICH, WD
BUSTO, R
SCHEINBERG, P
机构
[1] Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami
关键词
!sup]45[!/sup]Ca uptake; Cerebral ischemia; Dopamine; Excitotoxin; Striatum;
D O I
10.1016/0304-3940(87)90463-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The role of striatal dopamine (DA) in mediating ischemic neuronal death was studied in the rat. Two weeks after unilateral substantia nigra lesion, rats were subjected to 20 min of forebrain ischemia by 4-vessel occlusion. Morphological changes and 45Ca uptake were evaluated after 3 days of survival. In the DA-depleted striatum, the degree of ischemic neuronal damage and 45Ca uptake were markedly attenuated compared to the contralateral side. This study is the first to demonstrate that the presence of DA is a prerequisite for the development of ischemic injury in the striatum and that DA depletion protects the striatum from ischemic damage. © 1987.
引用
收藏
页码:251 / 256
页数:6
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