AN EFFECTIVE SYNTHESIS OF 2,2-DIFLUORO-3-HYDROXY ESTERS

被引：29

作者：

SHEN, YC

QI, M

机构：

[1] Shanghai Institute of Organic Chemistry, Academia Sinica, Shanghai, 200032

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1994年 / 67卷 / 03期

关键词：

D O I：

10.1016/0022-1139(93)02961-D

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reformatsky reactions of bromodifluoroacetate with carbonyl compounds and its applications to the synthesis of 2,2-difluoro-3-hydroxy esters as a means of two-carbon homologation with a difluoro moiety under mild conditions in good to excellent yields are described. In the case of aldehydes and aromatic ketones no catalyst was needed, while in the case of aliphatic ketones, 2 mol% of CeCl3 catalyst raises the yields dramatically from 30%-32% to 89%-92%.

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页码：229 / 232

页数：4

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