Phenytoin Toxicity During Neoadjuvant Concurrent Capecitabine and Radiation Therapy for Rectal Adenocarcinoma: Case Report of a Drug Interaction

被引：0

作者：

McGrath, Clare ^{[1
]}

Munro, Amy ^{[2
]}

Goel, Rakesh ^{[3
]}

Linden, Kelly ^{[4
]}

Dennis, Kristopher ^{[5
]}

机构：

[1] Univ Ottawa, Ottawa Hosp, Radiat Oncol, Canc Ctr, Ottawa, ON, Canada

[2] McMaster Univ, Fac Sci, Hamilton, ON, Canada

[3] Ottawa Hosp, Med Oncol, Ottawa, ON, Canada

[4] Ottawa Hosp, Dept Radiat Med, Canc Ctr, Ottawa, ON, Canada

[5] Univ Ottawa, Div Radiat Oncol, Ottawa, ON, Canada

来源：

CUREUS | 2018年 / 10卷 / 11期

关键词：

capecitabine; drug interaction; phenytoin; rectal cancer; 5-fluorouracil;

D O I：

10.7759/cureus.3625

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Phenytoin toxicity occurs when serum levels exceed the therapeutic level, leading to symptoms such as nystagmus, slurred speech, and decreased coordination. This toxicity is sometimes caused by drug interactions. Interactions between phenytoin and capecitabine are not commonly documented. We report the case of a 52-year-old man taking phenytoin for atypical meningioma who developed symptoms of phenytoin toxicity while receiving capecitabine in the treatment of rectal adenocarcinoma.

引用

页数：5

共 9 条

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