A POTENT, ORALLY-ACTIVE, BALANCED AFFINITY ANGIOTENSIN-II AT(1) ANTAGONIST AND AT(2) BINDING INHIBITOR

被引:124
作者
DELASZLO, SE [1 ]
QUAGLIATO, CS [1 ]
GREENLEE, WJ [1 ]
PATCHETT, AA [1 ]
CHANG, RSL [1 ]
LOTTI, VJ [1 ]
CHEN, TB [1 ]
SCHECK, SA [1 ]
FAUST, KA [1 ]
KIVLIGHN, SS [1 ]
SCHORN, TS [1 ]
ZINGARO, GJ [1 ]
SIEGL, PKS [1 ]
机构
[1] MERCK RES LABS,DEPT PHARMACOL,W POINT,PA 19486
关键词
D O I
10.1021/jm00073a024
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:3207 / 3210
页数:4
相关论文
共 24 条
[1]   SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A NOVEL SERIES OF NONPEPTIDE ANGIOTENSIN-II RECEPTOR-BINDING INHIBITORS SPECIFIC FOR THE AT2 SUBTYPE [J].
BLANKLEY, CJ ;
HODGES, JC ;
KLUTCHKO, SR ;
HIMMELSBACH, RJ ;
CHUCHOLOWSKI, A ;
CONNOLLY, CJ ;
NEERGAARD, SJ ;
VANNIEUWENHZE, MS ;
SEBASTIAN, A ;
QUIN, J ;
ESSENBURG, AD ;
COHEN, DM .
JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (11) :3248-3260
[2]  
BUHLMAYER P, 1992, CURRENT OPINION THER, P1693
[3]  
CHANG RSL, 1990, MOL PHARMACOL, V37, P347
[4]  
CHANG RSL, 1992, J PHARMACOL EXP THER, V262, P133
[5]   ORAL-ADMINISTRATION OF DUP-753, A SPECIFIC ANGIOTENSIN-II RECEPTOR ANTAGONIST, TO NORMAL-MALE VOLUNTEERS - INHIBITION OF PRESSOR-RESPONSE TO EXOGENOUS ANGIOTENSIN-I AND ANGIOTENSIN-II [J].
CHRISTEN, Y ;
WAEBER, B ;
NUSSBERGER, J ;
PORCHET, M ;
BORLAND, RM ;
LEE, RJ ;
MAGGON, K ;
SHUM, L ;
TIMMERMANS, PBMWM ;
BRUNNER, HR .
CIRCULATION, 1991, 83 (04) :1333-1342
[6]  
DELASZLO SE, 1993, CHEM LETT, V3, P1299
[7]   THE DISCOVERY OF POTENT NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - A NEW CLASS OF POTENT ANTIHYPERTENSIVES [J].
DUNCIA, JV ;
CHIU, AT ;
CARINI, DJ ;
GREGORY, GB ;
JOHNSON, AL ;
PRICE, WA ;
WELLS, GJ ;
WONG, PC ;
CALABRESE, JC ;
TIMMERMANS, PBMWM .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (05) :1312-1329
[8]  
ERDOES EG, 1986, HYPERTENSION, V8, P40
[9]  
GARRISON J C, 1990, P749
[10]   EFFECTS OF LOSARTAN ON BLOOD-PRESSURE, PLASMA-RENIN ACTIVITY, AND ANGIOTENSIN-II IN VOLUNTEERS [J].
GOLDBERG, MR ;
TANAKA, W ;
BARCHOWSKY, A ;
BRADSTREET, TE ;
MCCREA, J ;
LO, MW ;
MCWILLIAMS, EJ ;
BJORNSSON, TD .
HYPERTENSION, 1993, 21 (05) :704-713