COMPARATIVE STUDIES ON UROKINASE AND PLASMINOGEN ACTIVATOR FROM CULTURED PANCREATIC-CARCINOMA

被引：7
作者：
WU, MC
YUNIS, AA
机构：
[1] UNIV MIAMI, SCH MED, DEPT BIOCHEM, MIAMI, FL 33136 USA
[2] HOWARD HUGHES MED INST, MIAMI, FL 33101 USA
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1979年 / 10卷 / 12期
关键词：
D O I：
10.1016/0020-711X(79)90080-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. 1. Plasminogen activator (PA) from a human pancreatic carcinoma cell line and human urinary urokinase (UK) have been purified to homogeneity. Amino acid analysis indicated they have a similar amino acid composition. 2. 2. Antibodies against both PA and UK were prepared in rabbits. Immunodiffusion experiments revealed that both enzymes were immunologically identical. 3. 3. Antibodies against PA and UK cross inhibited PAs from several other human cancer cell lines, but did not inhibit PA from cultured rat breast carcinoma R2426 cells. © 1979.
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页码：1001 / 1006
页数：6
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