Design, Synthesis and Antibacterial Activity Studies of Novel Quinoline Carboxamide Derivatives

被引：16

作者：

Shivaraj, Yellappa ^{[1
]}

Naveen, Malenahalli H. ^{[1
]}

Vijayakumar, Giriyapura R. ^{[2
]}

Kumar, Doyijode B. Aruna ^{[2
]}

机构：

[1] Govt Sci Coll, Dept Chem, Bangalore 560001, Karnataka, India

[2] Tumkur Univ, Dept Chem, Tumkur 572103, India

来源：

JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE | 2013年 / 57卷 / 02期

关键词：

Quinoline-6-carboxamides; 2-Chloro quinoline-4-carboxamides; Antibacterial activity;

D O I：

10.5012/jkcs.2013.57.2.241

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel quinoline-6-carboxamides and 2-chloroquinoline-4-carboxamides were synthesized by the reaction of their analogous carboxylic acids with various amine derivatives in the presence of base TEA and protecting agent BOP at room temperature. Synthesized compounds were confirmed by spectral characterization viz IR, 1 H-NMR, and MS. Antibacterial activity carried out against Escherichia coli and Staphyllococcus aureus indicated that the synthesized compounds were active against these microorganisms.

引用

页码：241 / 245

页数：5

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