Host factors are dominant in the development of post-liver transplant non-alcoholic steatohepatitis

被引：5

作者：

Boga, Salih ^{[1
]}

Munoz-Abraham, Armando Salim ^{[2
]}

Rodriguez-Davalos, Manuel, I ^{[2
]}

Emre, Sukru H. ^{[2
]}

Jain, Dhanpat ^{[3
]}

Schilsky, Michael L. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Div Digest Dis, Dept Med & Surg,Sect Transplantat & Immunol, 333 Cedar St,LMP 1080, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Surg, Sect Transplantat & Immunol,Yale New Haven Transp, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA

来源：

WORLD JOURNAL OF HEPATOLOGY | 2016年 / 8卷 / 15期

关键词：

Liver; Split graft; Steatohepatitis; Host factors; Transplant;

D O I：

10.4254/wjh.v8.i15.659

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Non-alcoholic fatty liver disease (NAFLD) is a recognized problem in patients after orthotopic liver transplantation and may lead to recurrent graft injury. As the increased demand for liver allografts fail to match the available supply of donor organs, split liver transplantation (SLT) has emerged as an important technique to increase the supply of liver grafts. SLT allows two transplants to occur from one donor organ, and provides a unique model for observing the pathogenesis of NAFLD with respect to the role of recipient environmental and genetic factors. Here we report on two recipients of a SLT from the same deceased donor where only one developed non-alcoholic steatohepatitis (NASH), suggesting that host factors are critical for the development of NASH.

引用

页码：659 / 664

页数：6

共 21 条

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