APOLIPOPROTEIN-B MESSENGER-RNA EDITING - AN UPDATE

被引：13

作者：

CHAN, L ^{[1
]}

机构：

[1] BAYLOR COLL MED,DEPT MED,HOUSTON,TX 77030

来源：

BIOCHIMIE | 1995年 / 77卷 / 1-2期

关键词：

RNA EDITING; APOLIPOPROTEIN B; CYTIDINE DEAMINASE;

D O I：

10.1016/0300-9084(96)88107-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apolipoprotein (ape) B mRNA editing consists of a C --> U conversion of the first base of the codon CAA encoding glutamine 2153 in apoB mRNA to UAA, a stop codon. The cDNA for an apoB mRNA editing protein was recently cloned in rat and human. The human protein contains 236 amino acid residues and exists as a homodimer. The editing protein edits apoB mRNA. in vitro only in the presence of tissue complementation factors. There is a leucine-rich motif spanning residues 173-210 of the protein which may be involved in homodimer formation and/or interaction with complementation factors. The requirements for these factors support the existence of an editosome involved in apoB mRNA editing.

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页码：75 / 78

页数：4

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