IN-VITRO ACTIVATION AND DETECTION OF ANTIBODY-SECRETING CELLS FROM TRYPANASOMA CONGOLENSE INFECTED CATTLE

被引：5

作者：

TAYLOR, KA ^{[1
]}

GICHUKI, B ^{[1
]}

LUTJE, V ^{[1
]}

NAESSENS, J ^{[1
]}

WILLIAMS, DJL ^{[1
]}

机构：

[1] UNIV LIVERPOOL,LIVERPOOL SCH TROP MED,LIVERPOOL L3 5QA,MERSEYSIDE,ENGLAND

来源：

IMMUNOLOGY LETTERS | 1994年 / 43卷 / 03期

关键词：

BOVINE; B CELLS; ANTIBODY; TRYPANOSOMA CONGOLENSE;

D O I：

10.1016/0165-2478(94)90220-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cells from the peripheral blood and spleen of Trypanosoma congolense-infected cattle and from the peripheral blood of an uninfected cohort were analysed for ability to secrete antibody and for expression of surface antigens before and after in vitro culture with interleukin-2, lipopolysaccharide and pokeweed mitogen. Antibody-secreting cells (ASC) were only detected in lymphocytes from peripheral blood after in vitro stimulation. The frequency of ASC was greater in cultures of lymphocytes from infected cattle than from the uninfected cohort. The frequency of ASC was positively correlated with the number of B cells expressing the transferrin receptor but not with the expression of the CD5 antigen.

引用

页码：183 / 187

页数：5

共 26 条

[1] EARLY EVENTS FOLLOWING CHALLENGE OF CATTLE WITH TSETSE INFECTED WITH TRYPANOSOMA-CONGOLENSE - DEVELOPMENT OF THE LOCAL SKIN REACTION [J].

AKOL, GWO ;

MURRAY, M .

VETERINARY RECORD, 1982, 110 (13) :295-302

[2]

ASHMAN RF, 1990, J LAB CLIN MED, V116, P759

[3] ANTIBODY-RESPONSES TO INVARIANT ANTIGENS OF TRYPANOSOMA-CONGOLENSE IN CATTLE OF DIFFERING SUSCEPTIBILITY TO TRYPANOSOMIASIS [J].

AUTHIE, E ;

MUTETI, DK ;

WILLIAMS, DJL .

PARASITE IMMUNOLOGY, 1993, 15 (02) :101-111

[4] ANTIBODY-RESPONSES TO A 33 KDA CYSTEINE PROTEASE OF TRYPANOSOMA-CONGOLENSE - RELATIONSHIP TO TRYPANOTOLERANCE IN CATTLE [J].

AUTHIE, E ;

DUVALLET, G ;

ROBERTSON, C ;

WILLIAMS, DJL .

PARASITE IMMUNOLOGY, 1993, 15 (08) :465-474

[5] REGULATION OF DIFFERENTIATION IN CD5+ AND CONVENTIONAL B-CELLS - SENSITIVITY TO LPS-INDUCED DIFFERENTIATION AND INTERFERON-GAMMA-MEDIATED INHIBITION OF DIFFERENTIATION [J].

CHACE, JH ;

ABED, NS ;

ADEL, GL ;

COWDERY, JS .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1993, 68 (03) :327-332

[6]

COLLINS RA, 1993, VET IMMUNOL IMMUNOP, V39, P431

[7] POTENTIAL VALUE OF LOCALIZED SKIN REACTIONS (CHANCRES) INDUCED BY TRYPANOSOMA-CONGOLENSE TRANSMITTED BY GLOSSINA-MORSITANS-CENTRALIS FOR THE ANALYSIS OF METACYCLIC TRYPANOSOME POPULATIONS [J].

DWINGER, RH ;

MURRAY, M ;

MOLOO, SK .

PARASITE IMMUNOLOGY, 1987, 9 (03) :353-362

[8] EXPRESSION AND REGULATION OF CD5 ON INVITRO ACTIVATED HUMAN B-CELLS [J].

FREEDMAN, AS ;

FREEMAN, G ;

WHITMAN, J ;

SEGIL, J ;

DALEY, J ;

LEVINE, H ;

NADLER, LM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (05) :849-855

[9]

GEIGY R, 1973, Acta Tropica, V30, P12

[10]

HOWARD CJ, 1989, ANIM GENET, V20, P351

← 1 2 3 →