SOLID-PHASE SYNTHESIS OF O-PALMITOYLATED PEPTIDES

被引：13

作者：

BRANTON, WD

FIELDS, CG

VANDRISSE, VL

FIELDS, GB

机构：

[1] UNIV MINNESOTA,DEPT LAB MED & PATHOL,BOX 107,420 DELAWARE ST SE,MINNEAPOLIS,MN 55455

[2] UNIV MINNESOTA,DEPT PHYSIOL,MINNEAPOLIS,MN 55455

[3] UNIV MINNESOTA,DEPT BIOCHEM,MINNEAPOLIS,MN 55455

[4] UNIV MINNESOTA,CTR BIOMED ENGN,MINNEAPOLIS,MN 55455

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(00)74037-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Solid-phase synthesis of an O-palmitoylated peptide has been achieved by either palmitoylation of the resin-bound peptide or synthesis of palmitoylated Fmoc-Thr and subsequent solid-phase incorporation. The desired peptides containing palmitoylated Thr were isolated by reversed-phase C18 HPLC. An O --> N acyl shift was encountered when palmitoylated Fmoc-Thr was utilized.

引用

页码：4885 / 4888

页数：4

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