THE EFFECT OF HYPOTHERMIA ON CHANGES IN ISOMETRIC CONTRACTILE FUNCTION IN SKELETAL-MUSCLE AFTER TOURNIQUET ISCHEMIA

被引：20

作者：

FISH, JS

MCKEE, NH

KUZON, WM

PLYLEY, MJ

机构：

[1] Microvascular Research Laboratory, Department of Surgery, University of Toronto, Toronto, Ont.

来源：

JOURNAL OF HAND SURGERY-AMERICAN VOLUME | 1993年 / 18A卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0363-5023(93)90348-7

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The effect of hypothermia on changes in contractile function of skeletal muscle observed after an episode of tourniquet ischemia has been investigated. Male Wistar rats were subjected to 2 hours of unilateral hypothermic (n = 33) or normothermic (n = 39) pneumatic tourniquet ischemia of a hind limb. Isometric contractile function was measured bilaterally from the gastrocnemius muscles after 1, 7, 14, 28, or 42 days of recovery. Compared to muscle subjected to normothermic ischemia, muscle that underwent hypothermic ischemia demonstrated more twitch tension at 1 day postischemia, higher maximum tetanic tension at all time periods, including 6 weeks after ischemia, and greater muscle weight at 6 weeks. Rat gastrocnemius muscle function is much better 1 day to 6 weeks after 2 hours of hypothermic ischemia than after 2 hours of normothermic ischemia. The results thus document the benefit of hypothermia during tourniquet ischemia in preventing or minimizing the changes in isometric contractile function observed after normothermic ischemia.

引用

页码：210 / 217

页数：8

共 29 条

[1]

Mackey, McCullough, Conlon, Et al., The costs of surgery for limb-threatening ischemia, Surgery, 99, pp. 26-34, (1986)

[2]

Blaisdell, The reperfusion syndrome, Microcirc Endothelium Lymphatics, 5, pp. 127-141, (1989)

[3]

Bruner, Safety factors in the use of the pneumatic tourniquet for hemostasis in surgery of the hand, J Bone Joint Surg, 33 A, pp. 221-224, (1951)

[4]

Bruner, Time, pressure, and temperature factors in the safe use of the tourniquet, Hand, 1-2, pp. 39-42, (1969)

[5]

Wilgis, Tourniquet ischemia, muscle anoxia, and operative edema, Symposium on Reconstructive Surgery, pp. 59-68, (1974)

[6]

Allen, Resistance of peripheral tissues to asphyxia at various temperatures, Surg Gynecol Obstet, 67, pp. 746-751, (1938)

[7]

Allen, Surgical considerations of temperature in ligated limbs, Am J Surg, 45, pp. 459-464, (1939)

[8]

Shehadi, Paletta, Cooper, Effect of hypothermia on circulatory responses in the canine hind limb after tourniquet ischemia, Surg Forum, 12, pp. 466-468, (1961)

[9]

Paletta, Willman, Ship, Prolonged tourniquet ischemia of the extremities: an experimental study on dogs, J Bone Joint Surg, 42 A, pp. 945-950, (1960)

[10]

Paletta, Shehadi, Mudd, Cooper, Hypothermia and tourniquet ischemia, Plastic and Reconstructive Surgery, 29, pp. 531-538, (1962)

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