THE EFFECTS OF DIETARY N - 3 FATTY-ACID IN ANIMAL-MODELS OF TYPE-1 AND TYPE-2 DIABETES

被引：10

作者：

SULLIVAN, DR ^{[1
]}

YUE, DK ^{[1
]}

CAPOGRECO, C ^{[1
]}

MCLENNAN, S ^{[1
]}

NICKS, J ^{[1
]}

COONEY, G ^{[1
]}

CATERSON, I ^{[1
]}

TURTLE, JR ^{[1
]}

HENSLEY, WJ ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT MED,SYDNEY,NSW 2006,AUSTRALIA

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 1990年 / 9卷 / 03期

关键词：

Diabetes; Membrane composition; n - 3 fatty acid;

D O I：

10.1016/0168-8227(90)90049-Y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied the incorporation of dietary n - 3 fatty acids from marine oils into red cell membranes, using animal models of type 1 diabetes (streptozotocin-treated Wistar rats) and type 2 diabetes (gold-thioglucose-injected CBA/T6 mice). In type 1 diabetic rats, eicosapentaenoic acid (EPA) and docosa-hexaenoic acid (DHA) were higher following marine oil supplementation, and the increase in EPA was significantly greater than in non-diabetic animals (3.4 ± 1.4% vs. 0.8 ± 1.6%). Marine oil supplementation also resulted in higher levels of EPA and DHA in mice, but the increases were quantitatively similar with and without type 2 diabetes. Improvement in glycosylated haemoglobin following n - 3 fatty acid feeding was only found in type 2 diabetes (6.5 ± 2.9% vs. 9.5 ± 1.2%). This was associated with a higher plasma insulin concentration (170 ± 40 vs. 136 ± 41 mU/ml). The theory that n - 3 fatty acids improve insulin sensitivity would have predicted a decrease in plasma insulin levels. Our results suggest that n - 3 fatty acids may modify insulin secretion. © 1990.

引用

页码：225 / 230

页数：6

共 26 条

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