PANMYELOPHTHISIS AND VIRAL HEPATITIS - EXPERIMENTAL INVESTIGATIONS WITH MURINE HEPATITIS VIRUS MHV3

90 infantile CF1-mice had been inoculated intraperitoneally with murine hepatitis virus3 (MHV3) in order to study reactions of the bone marrow. 15 of the infected animals died within 72 h, and the surviving 75 were sacrificed at intervals up to 180 h. Histological examination of the marrow of sternum and femur showed necroses of varying extension. With progressing time and in loose correlation to the different virus dilutions the necroses disappeared and reparative changes took place. Histological findings were virtually normal after 180 h. One animal developed an incomplete myelophthisis, two others hypoplastic marrows. The so far prevailing interpretation regarding the disturbance of blood forming cells during experimental hepatitis as a sign of maturation delay cannot be maintained. © 1969 S. Karger AG, Basel.