CHEMOENZYMATIC SYNTHESIS OF CHIRAL EPOXIDES - PREPARATION OF 4-PHENYL-2,3-EPOXYBUTANE AND 1-PHENYL-1,2-EPOXYPROPANE

被引：26

作者：

BESSE, P ^{[1
]}

RENARD, MF ^{[1
]}

VESCHAMBRE, H ^{[1
]}

机构：

[1] UNIV CLERMONT FERRAND,CHIM ORGAN BIOL LAB,CNRS,URA 485,F-63177 CLERMONT FERRAND,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 07期

关键词：

D O I：

10.1016/0957-4166(94)80167-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

All the stereoisomers of 4-phenyl-2,3-epoxybutane and 1-phenyl-1,2-epoxypropane (beta-methylstyrene oxide) have been prepared in three steps from 4-phenyl-2-butanone and 1-phenyl-2-propanone or 1-phenyl-1-propanone respectively. The key step is the microbiological reduction of the corresponding haloketones. These results confirm those previously described(1) and demonstrate that the chemoenzymatic synthesis of homochiral 2,3-epoxides is a general method that can be used whatever the starting ketone.

引用

页码：1249 / 1268

页数：20

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