LESION OF DOPAMINE MESOLIMBIC NEURONS BLOCKS BEHAVIORAL-EFFECTS INDUCED BY THE ENDOGENOUS ENKEPHALINS BUT NOT BY A MU-OPIOID RECEPTOR AGONIST

被引：18

作者：

CALENCOCHOUKROUN, G ^{[1
]}

DAUGE, V ^{[1
]}

GACEL, G ^{[1
]}

ROQUES, BP ^{[1
]}

机构：

[1] UFR SCI PHARMACEUT & BIOL,CNRS,UA498,INSERM,U266,4 AVE OBSERV,F-75270 PARIS 06,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 209卷 / 03期

关键词：

MU-OPIOID RECEPTOR AGONISTS (SELECTIVE); DELTA-OPIOID RECEPTOR AGONISTS (SELECTIVE); KELATORPHAN; 6-HYDROXYDOPAMINE (6-OHDA); VENTRAL TEGMENTAL AREA; NUCLEUS ACCUMBENS; LOCOMOTOR ACTIVITY;

D O I：

10.1016/0014-2999(91)90181-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lesioning of dopamine neurons by injection of 6-hydroxydopamine into the nucleus accumbens blocked the increased rearing activity measured in the open-field and induced by injection into the ventral tegmental area of: ((R)-3-(N-hydroxylcarboxamido-2-benzyl-propanoyl)-L-alanine), kelatorphan (complete inhibitor of enkephalin catabolism) or by (Tyr-D-Ser(OtBu)-Gly-Phe-Leu-Thr(OtBu)): BUBU (selective delta-agonist) but not the hypolocomotion evoked by the mu-agonist (Tyr-D-Ala-Gly-N(Me)-Phe-Glycol): DAMGO. This suggests the involvement of different neuronal pathways in mu and delta-effects.

引用

页码：267 / 271

页数：5

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