THE GENE FOR THE MICROSOMAL GLUTATHIONE S-TRANSFERASE IS ON HUMAN CHROMOSOME-12

被引：21

作者：

DEJONG, JL ^{[1
]}

MOHANDAS, T ^{[1
]}

TU, CPD ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,HARBOR MED CTR,DIV MED GENET,TORRANCE,CA 90509

来源：

GENOMICS | 1990年 / 6卷 / 02期

关键词：

D O I：

10.1016/0888-7543(90)90580-N

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The microsomal glutathione S-transferase (GST) is a unique membrane-bound GST structurally distinct from the cytosolic GSTs. A cDNA encoding this 154 amino acid protein has recently been isolated and characterized. Using the cDNA as the hybridization probe, we now report the assignment of the human microsomal GST gene to chromosome 12 through the use of a panel of mouse-human somatic cell hybrid lines. This locus has recently been designated as GST 12. In addition, genomic Southern blotting data suggest that the human microsomal GST is encoded by a single- or very-low-copy gene. Therefore, the human GST gene superfamily resides on at least four separate chromosomes: 1 (GST 1), 6 (GST 2), 11 (GST 3), and 12 (GST 12). © 1990.

引用

页码：379 / 382

页数：4

共 20 条

[1] ISOLATION OF A CDNA CLONE AND LOCALIZATION OF HUMAN GLUTATHIONE S-TRANSFERASE-2 GENES TO CHROMOSOME BAND 6P12 [J].

BOARD, PG ;

WEBB, GC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2377-2381

[2]

BOYER TD, 1986, J BIOL CHEM, V261, P6963

[3]

CHOW NWI, 1988, J BIOL CHEM, V263, P12797

[4] THE HUMAN-LIVER GLUTATHIONE S-TRANSFERASE GENE SUPERFAMILY - EXPRESSION AND CHROMOSOME MAPPING OF AN HB SUBUNIT CDNA [J].

DEJONG, JL ;

CHANG, CM ;

WHANGPENG, J ;

KNUTSEN, T ;

TU, CPD .

NUCLEIC ACIDS RESEARCH, 1988, 16 (17) :8541-8554

[5]

DEJONG JL, 1988, J BIOL CHEM, V263, P8430

[6]

HAYES JD, 1987, GLUTATHIONE S TRANSF, P3

[7]

Maniatis T., 1982, MOL CLONING

[8]

MANTLE TJ, 1987, GLUTATHIONE S TRANSF

[9] HUMAN MICROSOMAL GLUTATHIONE S-TRANSFERASE - ITS INVOLVEMENT IN THE CONJUGATION OF HEXACHLOROBUTA-1,3-DIENE WITH GLUTATHIONE [J].

MCLELLAN, LI ;

WOLF, CR ;

HAYES, JD .

BIOCHEMICAL JOURNAL, 1989, 258 (01) :87-93

[10] ASSIGNMENT OF HUMAN GENE FOR GALACTOSE-1-PHOSPHATE URIDYLTRANSFERASE TO CHROMOSOME-9 - STUDIES WITH CHINESE HAMSTER-HUMAN SOMATIC-CELL HYBRIDS [J].

MOHANDAS, T ;

SPARKES, RS ;

SPARKES, MC ;

SHULKIN, JD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5628-5631

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