INTERACTIONS BETWEEN CALCIUM-CHANNEL BLOCKERS AND THE ANTICONVULSANTS CARBAMAZEPINE AND PHENYTOIN

被引：36
作者：
BAHLS, FH
OZUNA, J
RITCHIE, DE
机构：
[1] UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
[2] UNIV WASHINGTON,SCH MED,DEPT REHABIL MED,SEATTLE,WA 98195
[3] UNIV WASHINGTON,SCH MED,DEPT PHYSIOL & BIOPHYS,SEATTLE,WA 98195
[4] VET ADM MED CTR,SEATTLE,WA 98108
来源：
NEUROLOGY | 1991年 / 41卷 / 05期
关键词：
D O I：
10.1212/WNL.41.5.740
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We describe a retrospective analysis of the frequency of adverse interactions between calcium channel blockers and anticonvulsant drugs (phenytoin and carbamazepine) in a series of 43 patients. Ten patients receiving carbamazepine and three patients receiving phenytoin exhibited symptoms or signs of toxicity. Toxicity occurred with both diltiazem and verapamil, but not with nifedipine. These results emphasize the need for careful clinical and laboratory monitoring of patients receiving both classes of medication.
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页码：740 / 742
页数：3
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