REVERSAL POTENTIAL OF GABA-INDUCED CURRENTS IN ROD BIPOLAR CELLS OF THE RAT RETINA

被引：18
作者：
YAMASHITA, M [1 ]
WASSLE, H [1 ]
机构：
[1] MAX PLANCK INST HIRNFORSCH,DEUTSCHORDENSTR 46,W-6000 FRANKFURT 71,GERMANY
来源：
VISUAL NEUROSCIENCE | 1991年 / 6卷 / 04期
关键词：
RAT; RETINA; ROD BIPOLAR CELL; GAMMA-AMINOBUTYRIC ACID; REVERSAL POTENTIAL; CHLORIDE; NYSTATIN;
D O I：
10.1017/S0952523800006635
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
GABA-induced whole-cell currents were measured in rod bipolar cells dissociated from the adult rat retina. The patch-clamp electrode contained nystatin, which made the cell membrane electrically permeable without rupture, thus retarding the rate of diffusion of Cl- ions from the patch pipette to the cell interior. The reversal potential of the GABA-induced currents was around - 70 mV at an extracellular Cl- concentration of 149 mM. We conclude that GABA generates hyperpolarizing responses in rod bipolar cells of the rat retina.
引用
收藏
页码：399 / 401
页数：3
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