Prognostic significance of osteopontin expression in non-small-cell lung cancer: A meta-analysis

被引：10
作者：
Zou, Xue-Lin [1 ]
Wang, Chun [2 ]
Liu, Ke [3 ]
Nie, Wen [4 ]
Ding, Zhen-Yu [1 ]
机构：
[1] Sichuan Univ, Div Thorac Canc, State Key Lab Biotherapy, West China Hosp,West China Med Sch,Canc Ctr, 37 GuoXue Lane, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, Dept Endocrinol, State Key Lab Biotherapy, West China Hosp,West China Med Sch, Chengdu 610041, Sichuan, Peoples R China
[3] Zigong Ctr Dis Control & Prevent, Dept Occupat Hlth & Radiol Hlth, Zigong 643000, Sichuan, Peoples R China
[4] Sichuan Univ, Sch Clin Med, Chengdu 610041, Sichuan, Peoples R China
来源：
MOLECULAR AND CLINICAL ONCOLOGY | 2015年 / 3卷 / 03期
基金：
中国国家自然科学基金;
关键词：
meta-analysis; non-small-cell lung cancer; osteopontin; prognosis;
D O I：
10.3892/mco.2015.517
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Osteopontin (OPN) plays an important role in the progression and metastasis of cancer. However, the role of OPN as a prognostic factor in non-small-cell lung cancer (NSCLC) remains controversial. The aim of this study was to investigate the association between OPN expression and prognosis in patients with NSCLC using a meta-analysis. Based on PubMed, Ovid Medline, Embase, ISI, ScienceDirect and SpringerLink databases, related articles published prior to January, 2013 were collected. A meta-analysis was conducted to investigate the association of OPN expression with overall survival (OS) and progression-free survival (PFS) in patients with NSCLC. Hazard ratio (HR) with 95% confidence interval (CI) was used to assess the strength of this association. A total of 6 studies, including 776 patients, were found to be eligible for the meta-analysis. No heterogeneity was observed in OS or PFS, whereas low OPN expression was found to be correlated with better OS (HR=0.57, 95% CI: 0.46-0.70) and PFS (HR=0.62, 95% CI: 0.49-0.77). This meta-analysis demonstrated an association of OPN with poor prognosis in NSCLC patients. However, prospective studies are required to confirm these findings.
引用
收藏
页码：633 / 638
页数：6
相关论文
共 31 条
[1]   Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial [J].
Albain, Kathy S. ;
Barlow, William E. ;
Shak, Steven ;
Hortobagyi, Gabriel N. ;
Livingston, Robert B. ;
Yeh, I-Tien ;
Ravdin, Peter ;
Bugarini, Roberto ;
Boehner, Frederick L. ;
Davidson, Nancy E. ;
Sledge, George W. ;
Winer, Eric P. ;
Hudis, Clifford ;
Ingle, James N. ;
Perez, Edith A. ;
Pritchard, Kathleen I. ;
Shepherd, Lois ;
Gralow, Julie R. ;
Yoshizawa, Carl ;
Allred, D. Craig ;
Osborne, C. Kent ;
Hayes, Daniel F. .
LANCET ONCOLOGY, 2010, 11 (01) :55-65
[2]   Prognostic significance of osteopontin expression in early-stage non-small-cell lung cancer [J].
Boldrini, L ;
Donati, V ;
Dell'Omodarme, M ;
Prati, MC ;
Faviana, P ;
Camacci, T ;
Lucchi, M ;
Mussi, A ;
Santoro, M ;
Basolo, F ;
Fontanini, G .
BRITISH JOURNAL OF CANCER, 2005, 93 (04) :453-457
[3]   Osteopontin expression in lung cancer [J].
Chambers, AF ;
Wilson, SM ;
Kerkvliet, N ;
OMalley, FP ;
Harris, JF ;
Casson, AG .
LUNG CANCER, 1996, 15 (03) :311-323
[4]   OSTEOPONTIN - A PROTEIN WITH DIVERSE FUNCTIONS [J].
DENHARDT, DT ;
GUO, XJ .
FASEB JOURNAL, 1993, 7 (15) :1475-1482
[5]   METAANALYSIS IN CLINICAL-TRIALS [J].
DERSIMONIAN, R ;
LAIRD, N .
CONTROLLED CLINICAL TRIALS, 1986, 7 (03) :177-188
[6]   Osteopontin expression and prognostic significance in non-small cell lung cancer [J].
Donati, V ;
Boldrini, L ;
Dell'Omodarme, M ;
Prati, MC ;
Faviana, P ;
Camacci, T ;
Lucchi, M ;
Mussi, A ;
Santoro, M ;
Basolo, F ;
Fontanini, G .
CLINICAL CANCER RESEARCH, 2005, 11 (18) :6459-6465
[7]   Bias in meta-analysis detected by a simple, graphical test [J].
Egger, M ;
Smith, GD ;
Schneider, M ;
Minder, C .
BMJ-BRITISH MEDICAL JOURNAL, 1997, 315 (7109) :629-634
[8]   Functional Heterogeneity of Osteopontin Isoforms in Non-small Cell Lung Cancer [J].
Goparaju, Chandra M. V. ;
Pass, Harvey I. ;
Blasberg, Justin D. ;
Hirsch, Nathalie ;
Donington, Jessica S. .
JOURNAL OF THORACIC ONCOLOGY, 2010, 5 (10) :1516-1523
[9]   Measuring inconsistency in meta-analyses [J].
Higgins, JPT ;
Thompson, SG ;
Deeks, JJ ;
Altman, DG .
BMJ-BRITISH MEDICAL JOURNAL, 2003, 327 (7414) :557-560
[10]   Uncertainty in heterogeneity estimates in meta-analyses [J].
Ioannidis, John P. A. ;
Patsopoulos, Nikolaos A. ;
Evangelou, Evangelos .
BMJ-BRITISH MEDICAL JOURNAL, 2007, 335 (7626) :914-916
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