RAPIDLY PROGRESSIVE DEMENTIA IN A PATIENT WITH THE LEWY BODY VARIANT OF ALZHEIMERS-DISEASE

被引：54

作者：

ARMSTRONG, TP

HANSEN, LA

SALMON, DP

MASLIAH, E

PAY, M

KUNIN, JM

KATZMAN, R

机构：

[1] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,M-024,LA JOLLA,CA 92093

[2] UNIV CALIF SAN DIEGO,DEPT PATHOL,LA JOLLA,CA 92093

[3] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,SAN DIEGO,CA 92103

[4] UNIV CALIF SAN DIEGO,MED CTR,ALZHEIMERS DIS RES CTR,SAN DIEGO,CA 92103

[5] SHARP MEM HOSP & REHABIL CTR,SAN DIEGO,CA

来源：

NEUROLOGY | 1991年 / 41卷 / 08期

关键词：

D O I：

10.1212/WNL.41.8.1178

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 65-year-old woman presented with a mild memory impairment, spatial disorientation, and poor task initiation. Progression was rapid over 3 months. She developed severe apathy, delusions, extrapyramidal features, and psychometrically quantified cognitive deterioration. Her brain showed many neocortical neuritic plaques and neurofibrillary tangles along with neocortical and brainstem Lewy bodies and temporal lobe spongiform vacuolization. This case is the most rapid deterioration documented of a patient with Alzheimer's disease and Lewy bodies.

引用

页码：1178 / 1180

页数：3

共 11 条

[1] LEWY BODY VARIANT [J].