NOVEL BENZOTHIOPHENECARBOXAMIDOTETRAZOLE, BENZOFURANCARBOXAMIDOTETRAZOLE, AND NAPHTHALENECARBOXAMIDOTETRAZOLE AS POTENTIAL ANTIALLERGY AGENTS

被引：76

作者：

CONNOR, DT ^{[1
]}

CETENKO, WA ^{[1
]}

MULLICAN, MD ^{[1
]}

SORENSON, RJ ^{[1
]}

UNANGST, PC ^{[1
]}

WEIKERT, RJ ^{[1
]}

ADOLPHSON, RL ^{[1
]}

KENNEDY, JA ^{[1
]}

THUESON, DO ^{[1
]}

WRIGHT, CD ^{[1
]}

CONROY, MC ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,DIV PARKE DAVIS PHARMACEUT RES,DEPT PHARMACOL,ANN ARBOR,MI 48105

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 05期

关键词：

D O I：

10.1021/jm00083a023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and antiallergic activity of a series of novel benzothiophene-, benzofuran-, and naphthalenecarbox-amidotetrazoles are described. A number of the compounds inhibit the release of histamine from anti-IgE stimulated basophils obtained from allergic donors. Optimal inhibition is exhibited in benzothiophenes with a 3-alkoxy substituent in combination with a 5-methoxy, 6-methoxy, or a 5,6-dimethoxy group. Compounds 13c (CI-959) also inhibited respiratory burst of human neutrophils and the release of mediators from anti-IgE-stimulated human chopped lung.

引用

页码：958 / 965

页数：8

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