REDUCED LEVELS OF ALPHA-1 (I) COLLAGEN MESSENGER-RNA IN CELLS IMMORTALIZED BY MUTANT P53 OR TRANSFORMED BY RAS

被引：4

作者：

EIZENBERG, O ^{[1
]}

OREN, M ^{[1
]}

机构：

[1] WEIZMANN INST SCI, DEPT CHEM IMMUNOL, IL-76100 REHOVOT, ISRAEL

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1129卷 / 01期

关键词：

P53; RAS; COLLAGEN; TRANSFORMATION; TUMOR SUPPRESSOR;

D O I：

10.1016/0167-4781(91)90209-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genes whose expression patterns are altered in a cell line immortalized by mutant p53 were isolated by differential screening of a cDNA library. Levels of alpha-1 (I) collagen mRNA were reduced in the majority of immortalized cell lines which greatly overproduced the transfected mutant p53. This may reflect a co-selection during the establishment of the cell lines, rather than a direct effect of p53 on alpha-1 (I) collagen gene expression. On the other hand, a more direct relationship could be demonstrated between the expression of activated ras and a reduction in alpha-1 (I) collagen mRNA. Such reduction could partially account for the effects of ras on cell shape and cell proliferation.

引用

页码：34 / 42

页数：9

共 12 条

[1] ALTERATIONS OF COLLAGEN MESSENGER-RNA EXPRESSION DURING RETINOIC ACID-INDUCED CHONDROCYTE MODULATION - ABSENCE OF UNTRANSLATED ALPHA-1 (I) MESSENGER-RNA IN HYALINE CHONDROCYTES
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FEBS LETTERS, 1994, 340 (1-2): : 71 - 77
[3] Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer
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FEBS LETTERS, 1997, 406 (03) : 263 - 266
[5] Opposite effects of p53 on enzymes of nucleotide metabolism in Rat1 cells and their substrains transformed by oncogenes N-ras or v-mos
Khramtsova, SN
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Potapova, GI
Semenyak, OY
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BIOCHEMISTRY-MOSCOW, 1995, 60 (11) : 1439 - 1443
[6] COLLAGEN TYPE-I MESSENGER-RNA LEVELS IN CULTURED HUMAN LAMINA-CRIBROSA CELLS - EFFECTS OF ELEVATED HYDROSTATIC-PRESSURE
YANG, JL
NEUFELD, AH
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EXPERIMENTAL EYE RESEARCH, 1993, 56 (05) : 567 - 574
[7] Deregulation of p53/p21Cip1/Waf1 pathway contributes to polyploidy and apoptosis of E1A+cHa-ras transformed cells after γ-irradiation
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Oncogene, 1999, 18 : 5611 - 5619
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[9] ALTERNATIVELY-SPLICED P53 MESSENGER-RNA IN THE FAA-HTC1 RAT HEPATOMA-CELL LINE WITHOUT THE SPLICE SITE MUTATIONS
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