DETERMINATION OF ALBUTEROL CONCENTRATIONS IN HUMAN PLASMA USING SOLID-PHASE EXTRACTION AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION

被引:31
作者
BLAND, RE
TANNER, RJN
CHERN, WH
LANG, JR
POWELL, JR
机构
[1] GLAXO INC,PHARMACEUT DEV,DEPT CLIN PHARMACOKINET,5 MOORE DR,RES TRIANGLE PK,NC 27709
[2] GLAXO GRP RES LTD,DEPT BIOCHEM PHARMACOL,WARE SG12 0DJ,HERTS,ENGLAND
关键词
Albuterol; fluorescence detection; high-performance liquid chromatography; human plasma; pharmacokinetic studies; routine sample analysis; solid-phase extraction;
D O I
10.1016/0731-7085(90)80085-4
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A fast, simple, and accurate method for determining albuterol concentrations in human plasma has been developed and validated for use in routine clinical analyses. This method involves a solid-phase extraction procedure using silica cartridges and normal-phase high-performance liquid chromatography with fluorescence detection. Regression analysis showed the method was linear over the standard curve range 1-16 ng ml-1. The percent recovery for albuterol and the internal standard, bamethane, at 5 ng ml-1 was found to be ≫90%. The newly developed method has been applied in the analysis of plasma samples from patients and healthy volunteers. © 1990.
引用
收藏
页码:591 / 596
页数:6
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