HUMAN ALPHA-TUMOR-NECROSIS-FACTOR DOES NOT DAMAGE CULTURES CONTAINING RAT SCHWANN-CELLS AND SENSORY NEURONS

被引：22
|
作者：
MITHEN, FA
COLBURN, S
BIRCHEM, R
机构：
[1] Department of Veterans Affairs, John Cochran Medical Center St. Louis, MO
[2] St. Louis University School of Medicine St. Louis, MO
来源：
NEUROSCIENCE RESEARCH | 1990年 / 9卷 / 01期
关键词：
A23187; Guillain-Barré; syndrome; Myelin sheath; Peripheral nerve disease; Schwann cells; Tissue culture; Tumor necrosis factor;
D O I：
10.1016/0168-0102(90)90046-H
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of recombinant human alpha tumor necrosis factor (alpha-TNF) were compared with those of cytotoxic serum from patients with the acute Guillain-Barré syndrome (GBS) in myelinated cultures containing only rat Schwann cells and dorsal root ganglion neurons. Alpha-TNF did not damage rat peripheral nervous system tissue in culture. These observations suggest that alpha-TNF is not responsible for the cytotoxic activity of acute GBS serum in culture. © 1990.
引用
收藏
页码：59 / 63
页数：5
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