EVALUATION OF A NUCLEASE-RESISTANT DERIVATIVE OF POLY(I).POLY(C) [POLY(ICLC)] AS A RADIOPROTECTIVE AGENT

被引：12
作者：
BAZE, WB
LYOVSKY, E
HIGBEE, GA
LEVY, HB
HILMAS, DE
机构：
[1] USA,INST MED RES INFECT DIS,FREDERICK,MD 21701
[2] NIAID,BETHESDA,MD 20014
来源：
RADIATION RESEARCH | 1979年 / 77卷 / 02期
关键词：
D O I：
10.2307/3575139
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Intramuscular injection of a stabilized polyriboinosinic acid/polyribocytidylic acid complex, composed of the two acids, poly-l-lysine and carboxymethylcellulose [poly(ICLC)], was radioprotective in mice when given in single or multiple doses before total-body irradiation. At low to moderately high dosages, LD50/30 values were increased significantly (P<0.05), with a maximum dose-reduction factor of 1.25. Survival rates and weighted mean survival times were also significantly increased. Increased circulating levels of serum interferon proportional to poly(ICLC) concentration were not required at the time of irradiation for radioprotection. Poly(ICLC) was found to have a slight stimulatory effect on the numbers of peripheral blood elements in irradiated mice.
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页码：276 / 284
页数：9
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