Background: Helicobacter pylori (H. pylori) infection has been associated with hyperglycemia and raised levels of inflammatory cytokines triggered in patients suffering from type 2 diabetes mellitus. Aim: To compare the frequency of H. pyloriinfection in diabetic and non-diabetic patients. Study Design: Case control. Place and Duration: Department of Pathology/Microbiology and Medicine outdoor department, Life Hospital, Lahore from June 2017 to March 2018. Methods: This hospital-based case control study was conducted on 180 subjects and were divided into two groups i. e. type 2 diabetics and non-diabetics. All diabetic patients of > 18 years of age, both gender and the known cases with history of indigestion, heart burn, pain or discomfort in the stomach or abdominal fullness for more than a month were screened for H. pylori infection. The collected data of both groups was evaluated and separated for analysis. Results: H. pylori infection was positive in75% of diabetic patients and only 25% in non-diabetic group with a highly significant p-value (0.000). In H. pylori infection positive diabetic group, majority of the patients were reported to be males with maximum age range of 41-50 years in both diabetic (30) and non-diabetic (10) patients. Conclusion: This study overall concludes that diabetic patients are at greater risk of H. Pylori infection. Hence, infection by this pathogen must be suspected in patients suffering from type 2 diabetes mellitus.
