INHIBITORY EFFECT OF NITRIC-OXIDE (NO) SYNTHASE INHIBITORS ON NALOXONE-PRECIPITATED WITHDRAWAL SYNDROME IN MORPHINE-DEPENDENT MICE

被引：68

作者：

CAPPENDIJK, SLT

DEVRIES, R

DZOLJIC, MR

机构：

[1] Department of Pharmacology, Faculty of Medical and Health Sciences, Erasmus University Rotterdam, 3000 DR Rotterdam

来源：

NEUROSCIENCE LETTERS | 1993年 / 162卷 / 1-2期

关键词：

MOUSE; MORPHINE WITHDRAWAL; NALOXONE; NITRIC OXIDE SYNTHASE INHIBITOR; L-NAME; L-NMMA; L-NOARG;

D O I：

10.1016/0304-3940(93)90569-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of intraperitoneally administered nitric oxide (NO) synthase inhibitors has been examined on the naloxone-precipitated withdrawal syndrome in morphine-dependent mice. L-NAME (30-200 mg/kg) and L-NOARG (7.5-50 mg/kg) induced a significant decrease of naloxone-precipitated withdrawal jumping and diarrhoea. However, L-NMMA (3.5-100 mg/kg), considered as a less potent NO synthase inhibitor, did not significantly affect the withdrawal signs in mice. Although a specificity of NO synthase inhibitors is not fully established, these results indicate that inhibition of NO synthesis in the central nervous system and periphery may significantly affect the morphine withdrawal phenomena. Accordingly, this study suggests an involvement of NO in morphine withdrawal syndrome.

引用

页码：97 / 100

页数：4

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