ANGIOTENSIN-CONVERTING ENZYME VARIABILITY IN HYPERTENSIVE AND NORMOTENSIVE RATS

被引:11
|
作者
MICHEL, B
WELSCH, C
COQUARD, C
GRIMA, M
BARTHELMEBS, M
IMBS, JL
机构
[1] UNIV STRASBOURG 1,INST PHARMACOL,CNRS,URA DO589,11 RUE HUMANN,F-67070 STRASBOURG,FRANCE
[2] HOP UNIV STRASBOURG,SERV MALAD VASC & HYPERTENS,STRASBOURG,FRANCE
关键词
KININASE-II; RATS; INBRED WKY; INBRED SHR;
D O I
10.1161/01.HYP.21.4.442
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Recent data have revealed biological and genetic variability in normotensive Wistar-Kyoto rats, which are considered to be the most appropriate control strain for spontaneously hypertensive rats. To investigate the possibility that angiotensin converting enzyme activity could be affected by this variability, we measured plasma and tissue (lung, heart, renal cortex, renal medulla, and adrenal gland) angiotensin converting enzyme activity in spontaneously hypertensive rats and normotensive Wistar-Kyoto rats from three commercial suppliers in France: Iffa-Credo, Janvier, and Charles River Laboratories. Angiotensin converting enzyme activity was measured in vitro with a fluorometric assay using carbobenzoxy-Phe-His-Leu as substrate. Angiotensin converting enzyme activity in both rat strains varied considerably from one supplier to another, and therefore, comparisons of spontaneously hypertensive rats and Wistar-Kyoto rats from the different suppliers produced conflicting results. For Wistar-Kyoto rats, angiotensin converting enzyme activity in the plasma, heart, kidney, and adrenal glands was highest in rats from Iffa-Credo and lowest in rats from Charles River. For spontaneously hypertensive rats, angiotensin converting enzyme activity in the plasma and tissues was highest in rats from Janvier, whereas no difference could be observed between rats from Iffa-Credo and Charles River. These data confirm the problem of how to interpret and compare studies that use spontaneously hypertensive and Wistar-Kyoto rat strains.
引用
收藏
页码:442 / 445
页数:4
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