ES-242-2, ES-242-3, ES-242-4, ES-242-5, ES-242-6, ES-242-7, AND ES-242-8, NOVEL BIOXANTHRACENES PRODUCED BY VERTICILLIUM SP, WHICH ACT ON THE N-METHYL-D-ASPARTATE RECEPTOR

被引：27
作者：
TOKI, S
ANDO, K
KAWAMOTO, I
SANO, H
YOSHIDA, M
MATSUDA, Y
机构：
[1] Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Tokyo 194, 3-6-6 Asahimachi, Machida-shi
来源：
JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 07期
关键词：
D O I：
10.7164/antibiotics.45.1047
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Verticillium sp. SPC-15898 was found to produce novel metabolites, designated ES-242-2 approximately -8, which were structurally related to ES-242-1. These compounds were isolated from the culture broth and the physico-chemical and biochemical properties were examined. ES-242-2 approximately -8 inhibited [H-3]thienyl cyclohexypiperidine ([H-3]TCP) binding to rat crude synaptic membranes (CSM) with IC50 values of 0.116, 2.9, ca. 2.9, 25.3, 1.0, 59, 24, and 13-mu-M, respectively. None of these compounds showed inhibitory effects against the binding of [H-3]kainate to its receptor, which is another subtype of the excitatory amino acid receptor.
引用
收藏
页码：1047 / 1054
页数：8
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