PYRIMETHAMINE RESISTANT PLASMODIUM-FALCIPARUM - OVERPRODUCTION OF DIHYDROFOLATE-REDUCTASE BY A GENE DUPLICATION

被引：57
作者：
INSELBURG, J
BZIK, DJ
HORII, T
机构：
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1987年 / 26卷 / 1-2期
关键词：
D O I：
10.1016/0166-6851(87)90136-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：121 / 134
页数：14
相关论文
共 26 条
[1]   PURIFICATION AND PROPERTIES OF ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE [J].
BACCANARI, D ;
PHILLIPS, A ;
SMITH, S ;
SINSKI, D ;
BURCHALL, J .
BIOCHEMISTRY, 1975, 14 (24) :5267-5273
[2]   PLASMODIUM-FALCIPARUM - INDUCTION, SELECTION, AND CHARACTERIZATION OF PYRIMETHAMINE-RESISTANT MUTANTS [J].
BANYAL, HS ;
INSELBURG, J .
EXPERIMENTAL PARASITOLOGY, 1986, 62 (01) :61-70
[3]   PRIMARY STRUCTURE OF THE GENE ENCODING THE BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF LEISHMANIA-MAJOR [J].
BEVERLEY, SM ;
ELLENBERGER, TE ;
CORDINGLEY, JS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (08) :2584-2588
[4]  
BRUICE TW, 1982, BIOCHEMISTRY, V21, P178
[5]   ALTERED DIHYDROFOLATE REDUCTASE ASSOCIATED WITH A PYRIMETHAMINE-RESISTANT PLASMODIUM-BERGHEI-BERGHEI PRODUCED IN A SINGLE STEP [J].
DIGGENS, SM ;
GUTTERIDGE, WE ;
TRIGG, PI .
NATURE, 1970, 228 (5271) :579-+
[6]   A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].
FEINBERG, AP ;
VOGELSTEIN, B .
ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13
[7]  
FEINBERG AP, 1984, ANAL BIOCHEM, V137, P266
[8]  
FERONE R, 1969, MOL PHARMACOL, V5, P49
[9]  
FERONE R, 1970, J BIOL CHEM, V245, P850
[10]  
FERONE R, 1977, B WORLD HEALTH ORGAN, V55, P291
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